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Evaluation of Novel H1N1 Influenza A Virus Vaccine Effectiveness in Children

Influenza is an important and often poorly controlled cause of morbidity, mortality, and healthcare burden among children. Multiple studies have established that annual influenza vaccination for children prevents a significant number of influenza infections, hospitalizations, and deaths.

Abt Global, in collaboration with the Centers for Disease Control and Prevention and our subcontractor Children’s Hospital of Boston, used a case-control design to evaluate the effectiveness of seasonal and 2009 H1N1 vaccine in preventing laboratory-confirmed influenza infection associated with admission to an intensive care unit (ICU) among children aged 6 months to 17 years during the 2010-2011 influenza season. 

The study’s secondary objectives were to:
  • Identify factors that may mitigate the course and severity of outcomes of influenza among vaccinated and unvaccinated individuals;
  • Identify non-influenza sources of infections and co-infections in ICU patients aged 6 months to 17 years, and to assess how infecting organism type or presence of co-infection influences outcomes in comparison to infection with influenza; and
  • Assess specificity and sensitivity of alternative sampling sites and methods for detection of influenza and other pathogens among children aged 6 months to 17 years in ICUs.
Read more about this research:
Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in U.S. children, 2010-2012, The Journal of Infectious Diseases, Ferdinands, J.M., Olsho, L.E.W., Agan, A.A., Bhat, N., Sullivan, R.M., Hall, M., Mourani, P.M., Thompson, M., & Randolph, A.G. (2014).
Variability in IRBs regarding parental acceptance of passive consent. Pediatrics, Higgerson, R.A., Olsho, L.E.W., Christie, L.M., Rehder, K., Doksum, T., Gedeit, R., Giuliano, J.S., Brennan, B., Wendlandt, R., & Randolph, A.G. (2014).
North America