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Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012

Jill M. Ferdinands, Lauren E.W. Olsho, Anna A. Agan, Niranjan Bhat, Ryan M. Sullivan, Mark Hall, Peter M. Mourani, Mark Thompson, Adrienne G. Randolph


March 27, 2015
No studies have examined the effectiveness of influenza vaccine against intensive care unit (ICU) admission associated with influenza virus infection among children.
In 2010–2011 and 2011–2012, children aged 6 months to 17 years admitted to 21 US pediatric intensive care units (PICUs) with acute severe respiratory illness and testing positive for influenza were enrolled as cases; children who tested negative were PICU controls. Community controls were children without an influenza-related hospitalization, matched to cases by comorbidities and geographic region. Vaccine effectiveness was estimated with logistic regression models. 
North America