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ATSDR Toxicological Profiles


  • ATSDR wanted to better understand the characteristics of 13 hazardous chemicals found in NPL sites.
  • Abt is conducting literature reviews, dose-response modeling, and more.
  • Our findings will be summarized in toxicological profiles.
The Challenge

The Agency for Toxic Substances and Disease Registry (ATSDR) wanted to better understand the characteristics of 13 chemicals with a range of potential health effectsincluding neurological, hematological, hepatic, and renalfound on the Superfund National Priorities List (NPL). Abt was hired to provide an analysis and partner with ATSDR in writing a publicly available report to inform health professionals, private sector organizations, and the public of the findings.

The Approach

Abt’s analysis of the chemicals will consist of literature reviews (including systematic reviews), data extraction, dose-response modeling, and developing non-regularity Minimal Risk Levels (MRLs) to better understand the health effects associated with exposure to the chemicals. Abt also will present in the profile analyses of:

  • The presence of the chemical at NPL sites,
  • Biomonitoring data from NHANES,
  • Emissions and water quality data from sources such as EPA’s Toxics Release Inventory (TRI),  Water Quality Portal (STORET/WQP), Unregulated Contaminant Monitoring Rule (UCMR) data, and air quality system (AQS) data,
  • FDA’s Total Diet Study (TDS), as well as
  • The potential for human exposure from foods and other sources, as documented in the literature.
The Results

Abt’s work will be summarized in toxicological profiles, which will go through inter- and intra-agency review and peer review. Abt will also write summary documents known as ToxFAQs and ToxGuides to provide a short overview of each toxicological profile.

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